Similar to what GA-Bandit said,
I commuted with my Harley for a few weeks on regular gas, and then for the same number of trips using premium. The loss of mpg with the regular was in excess of the premium paid for premium. It mathematically came out advantageous to use premium. I then tried the same experiment with my Mini Cooper S, same result! I have not gone back to regular...
In addition, there was one hill, about 800' of elevation gain in about 3 miles on the way home from work. I would get the bike to 55 approaching the hill, and then click on the cruise control. In 5th gear, on premium, the bike would pull all the way and maintain speed. On regular, I had to down shift to 4th to get it to pukk the hill at 55.
So, almost a 15% increase in mileage, slightly increased performance, and less that a 12% increase in cost. Premium won!