I'm sure there are other routes, but when we leave from the San Antonio area we meet in Junction and take what we call Juno road to make it fun. Going thru F'burg and taking all the really twisty roads down to Del Rio just makes it too long a day for me. So I usually skip that part since I can do it anytime I want and go I-10.
Rock Springs has a gas station that makes some of the best breakfast tacos you can find. We basically take the twisty roads south of I-10 starting at Sonora, Ozona or a milepost I don't remember if I want to stop at Fort Lancaster park for a cigar. Whatever cutoff we take, we go thru the dead town of Juno that's still on some maps, on the roads that follow the river.
End up at Comstock and then over to Pecos River Bridge for a stop if we're taking a really long relaxed day. We skip JRBean's, I remember when it was a little store that sold dead AA batteries and wormy candy bars.
From there on 90 its kind of boring til you get to BBNP or til you get past Alpine. I believe Sanderson is the last place to get 92octane gas. After Alpine on the way to Fort Davis the road gets twisty and is some of the prettiest in the area.
To someone who's never been there before it must seem like there's nothing to do. But the fact is I can think of dozens of great options, things to see and unique experiences. Its just all spread out and you've got to know what to look for I guess. There are dozens of threads on here but no consolidated list that I know of.
Regardless of how you go, when I took the car it was just a slog of a drive to get there. When I take the bike its always fun no matter how many times I've done it. I've even been to FDavis on the bike and never started the bike the entire weekend. It was still more fun that being in a car. Just my opinion.
Ride. take old 90 west of san Antonio all the way to either marathon or alpine.
From the west side of Del rio just before lake Amistad get gas and the next gas stop is sanderson at right about 100 miles. Judge Roy beans place in Langtree is in between there.
you will love old 90