I know that if the wife has "decided" then it is probably too late to toss my 2 cents in the hat. However, I agree with jfink. I used to run tour groups in that area and we stayed in Montrose each time. The hotels are much cheaper. The restaurants are cheaper. It is ideally located to do at least four different loops that run about 300-350 miles per day. Each loop is different in terms of scenery, but all are great riding.
We usually stayed on the East end of Montrose at the
Best Western Red Arrow. It is on US 50. Very bike friendly. Room for trailer parking. Nice rooms. Pool and hot tub. Several good restaurants in close walking distance (liquor store as well if you like). A HonYamSuz and few other things dealer a few blocks away. Rates were always very reasonable.
Jfinks' map shows most of the loops.
1. Montrose --> Durango --> Cortez --> Telluride --> Ridgway --> Montrose
Includes run down US 550 - The Million Dollar Highway
Can see the Mesa Verde Cliff Dwellings
Lizzard Head Pass going up to Telluride
Great view of the San Juans as you cut back over to Ridgway
2. Montrose --> Ridgway --> Placerville --> Naturita --> Gateway --> Grand J --> Montrose
This has the great run up to Gateway on 145.
Can get lunch in Grand J, then do the Colorado Nat Mon.
If you are ready to quit for the day, head back down 50 to Montrose
If you want more, head West from GJ to Hwy 65 for run over Grand Mesa.
3. Montrose --> Lake City --> Creede --> backtrack to Montrose
See the Black Canyon of the Gunnison
See the Cimmaron Railroad museum
Make
excellent run down to Creede over Slumgullion Pass
See headwaters of the Rio Grande river
Lunch at Poker Alice's in Lake City
4. Montrose --> Blue Mesa Reservoir --> Hotchkiss --> Glennwood Springs --> Grand Mesa --> Montrose
Run Hwy 92 up the Northside of Black Canyon
Run up over Mc Clure Pass on 133
Visit Glennwood Springs
Run Grand Mesa (never had anyone gripe about doing it twice
)
All four of those routes are fantastic riding and scenery. If your bikes can do at least 100 miles on a tank of gas, you should be fine. When I ran the tours, we would start at 9:00am and usually be back to the hotel in Montrose by 6:00pm-ish. That included stops for pictures, lunch, gas. It usually did NOT include long stops for sight seeing (like more than 10-15 minutes).
I was just out there at the end of April and rode Hwy 145 up to Gateway, the Colorado Nat Monument, and 550 between Ridgway and Durango. There was still a LOT of snow on the ground at high elevations. It was very pretty. However, the ice and sand on 550 was a bit puckering... That won't be a problem when you are looking to go.
I would only stay in Durango if you will be doing more sightseeing off the bike, like riding the train to Silverton.