For simplicity and reliability, probably a DR650 with a few modifications. Even the 1st gen KLR has a radiator that is easily damaged (or the fan) in a mild drop.
The CRF 300 L seems to be very popular right now with people already traveling the world. Most of them will tell you that big power is not really needed because you will RARELY be in a place where you can use it, especially for higher speeds. I have seen two in person that hit the ground quite hard and they came out of it in pretty good condition... unlike their riders.
I really like my 701. It is light and has loads of power. It handles paved and unpaved very well. In stock form, the gas storage is limited, but there are several solutions for that, one of which allows you to carry nearly 13 gallons in fixed tanks instead of fuel bladders or extra containers. The issue they might have is fuel pump related. I don't remember exactly what the issue has been, but the pump is easy to get to and replace if you can source one. Realistically, sourcing parts is not that big of an issue because there seems to be internet access even in very remote places and UPS or someone can get stuff to you. At best, it might be an issue of how long you have to wait for a part. This was not the case in the pre-internet days and bike simplicity and ease of working on it counted a lot more than it might nowadays. Having done one long trip, I am a BIG believer in taking days off every 5-6 days minimum, so that might provide me an excuse to take such a break.
The issue of breaking down in the middle of nowhere is also not as big a deal as most people imagine. If you follow any actual world travelers and look that their experiences, they almost always have someone that finds them and is willing to help. The break down or problem might not be part of the plan, but it becomes part of the adventure. If you listen to interviews or watch videos of them, they will almost all be very positive about those experiences. While I have not traveled the world, I did have similar experiences on our 50 day trip riding in some fairly remote areas. With the advent of tech like the SPOT/InReach, satellite phones, Starlink, etc,... That is even less of a worry. All this to say, I think in our current age I would trade a bit of simplicity for comfort and moderate tech.
One bit of tech that I REALLY like on my GS is the ride modes that not only affect power delivery, but also change the suspension settings on the fly. I don't have to constantly fiddle with preload for luggage or no luggage, I don't have to mess with damping/rebound settings. That all happens automagically. Cruise control is also nice when needed. The weight of the GS would limit where I might choose to go. So realistically, I might be looking at something like a KTM 890 Adventure R/Husky 901 as a compromise.
It would be nice if the manufacturers of the adventure bikes would design them with default "failure" modes. What I mean by this is that if any of the software stuff glitches, the bike can still fall back to some kind of manual mode that just gets the bike ridable, and I don't mean in some first gear only "crippled" model. I mean that it basically acts like an old school bike that you can ride without all the extras. I get that a bad fuel injector can't necessarily have a "manual" mode. But, maybe there might be a way to have it ignore the need for sensors and just spray the gas based on RPMs only, kind of like a carb. Also, things like side stand sensors, tip over sensors, clutch lever sensors, etc,... need to have some means of being over ridden. On a recent ride, we came within minutes of calling for help because a Triumph fell over and something went wonky with the sensors. It would start, but standing it upright off the stand would kill it, putting the stand up while keeping it leaned at the same angle would kill it, and basically there was no way to ride it out. After 20-30 minutes of messing with it and being about to give up, it just magically started working again
All the nanny stuff is fine just so long as there is a way to tell it, "YES!! I KNOW there is a problem. Do your job anyway!!" After all, to me, being stranded is just as big of a concern as accidentally starting my bike in gear or riding off with the side stand down.
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